Male Factors: An Ignored Etiology in Recurrent Pregnancy Loss
نویسندگان
چکیده
ENGLISH/ANGLAIS] Affiliations: 1 Human Genetics Laboratory, Department of Studies in Zoology, University of Mysore, Manasagangothri, Mysore, Karnataka, INDIA 2 Mediwave IVF and Fertility Research Hospital, Mysore, Karnataka, INDIA * Email Address for Correspondence/ Adresse de courriel pour la correspondance: [email protected]. in Accepted/Accepté: August, 2011 Full Citation: Chaithra PT, Sreenivasa G, Vineeth VS, Kavitha P, Najafi M, Kumar S, Malini SS. Male Factors: An Ignored Etiology in Recurrent Pregnancy Loss. World Journal of Life Sciences and Medical Research 2011;1(4):76-82. The etiologies of recurrent pregnancy loses could be chromosomal aberrations, uterine defects, immunological problems, endocrinological problems, advanced reproductive age, sperm deformities and gene mutations. But most often the male factors are neglected and not consider as major factor in Pregnancy loss. In male partner of the patients with recurrent pregnancy loss RPL have a significant increase in sperm DNA fragmentation and decreased sperm functions. This study was conducted to evaluate the correlation between male factors and pregnancy loss. In our study with 50 idiopathic RPL cases 30 cases were identified with female factors responsible for RPL, 7 cases with both male and female eitiologiesand rest 13 were idiopathic. Randomly selected males were taken as controls with proven fertility rate and compared with RPL group. The semen samples of the respective male partners were analysed along with basic semen analysis procedures. Sperm function test was carried out by Hypo-osmotic swelling test (HOS), Acrosomal Reaction (AR) and Nuclear decondensation test (NCD). Sperm motility, viability and sperm function tests scores were significantly lower in the RPL group when compared to the control group. Through this pilot study it is significant that male factor might be a possible contributing factor towards RPL. Therefore both the partners should be evaluated and treated simultaneously in order to achieve successful pregnancy.
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